![]() Cut-off values were tested on patients with Alzheimer's disease and a small sample of patients with probable idiopathic normal pressure hydrocephalus (iNPH) to assess the sensitivity. The cut-off for pathological ventricular enlargement was estimated from healthy elderly categorized into age groups of 5 years range and defined as EI 97,5 percentile (mean+2SD). We propose new age and sex specific cut-off values for ventricular enlargement in the elderly population.ĥ34 participants (53% women) aged 65-84 years 226 patients with Alzheimer's disease (AD), and 308 healthy elderly controls (CTR) from the AddNeuroMed and ADNI studies were included. However, normal range for EI measured on magnetic resonance imaging (MRI) scans are lacking in healthy elderly according to age and sex. Linear indices, such as the Evans Index (EI), have been proposed as markers of ventricular volume with an EI≥0.3 indicating pathologic ventricular enlargement in any subject. 9 Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway Department of Life Sciences and Health, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, Oslo, Norway.Īssessment of ventricular enlargement is subjective and based on the radiologist's experience.8 Oslo Center for Biostatistics and Epidemiology, Department of Biostatistics, University of Oslo, Oslo, Norway.7 Department of Neurology, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway Department of Neurology, Division of Surgery and Clinical Neuroscience, Oslo University hospital, Oslo, Norway.6 Department of Radiology, Haukeland University Hospital, Bergen, Norway.5 Department of Neurosurgery, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway Department of Neurosurgery, Oslo University Hospital, Oslo, Norway. ![]() 4 Department of Radiology and Nuclear Medicine, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.3 Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden Institute of Psychiatry, King's College London, UK NIHR Biomedical Research Centre for Mental Health, London, UK NIHR Biomedical Research Unit for Dementia, London, UK.Electronic address: 2 Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden Institute of Psychiatry, King's College London, UK. 1 Department of Radiology, Haukeland University Hospital, Bergen, Norway Department of Clinical Medicine (K1), University of Bergen, Bergen, Norway.
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